Background: Vitamin D deficiency and vitamin D receptor gene polymorphisms are known to be significantly\nassociated with high myopia. Whether this genetic variant may impact primary open-angle glaucoma is\nlargely unknown. This study investigated whether vitamin D receptor gene polymorphisms are altered in\nprimary open-angle glaucoma subjects carrying the risk allele, and whether vitamin D deficiency is an\nimportant factor in the development of glaucoma.\nMethods: Seventy-three POAG patients and 71 age-matched controls from the Han population were enrolled. Serum\nlevels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay. Vitamin D receptor\npolymorphisms (Cdx-2, Fok I, Bsm I and Taq I) were analyzed using real-time polymerase-chain reaction high resolution\nmelting analysis.\nResults: Serum levels of 1a, 25-Dihydroxyvitamin in primary open-angle glaucoma patients were lower than in\nage-matched controls. Statistical analysis revealed a significant difference in the allelic frequencies of the BsmI and TaqI\ngenotypes between primary open-angle glaucoma patients and age-matched controls, while other polymorphisms did\nnot show any significant differences.\nConclusions: Vitamin D deficiency and the presence of the BsmI ââ?¬Ë?Bââ?¬â?¢ allele and the TaqI ââ?¬Ë?tââ?¬â?¢ allele are relevant risk factors in\nthe development of glaucoma.
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